Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.41 |
| ▸ | RAB9A | P51151 | 11/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179465 | 0.92 | KDR (0.42) | NPC1RAB9APOLBKDRCASP3 | |
| SCHEMBL13719378 | 0.92 | KDR (0.42) | NPC1RAB9APOLBKDRCASP3 | |
| SCHEMBL2178455 | 0.89 | LMNA (0.40) | KDRMEN1KMT2ALMNATP53 | |
| SCHEMBL2179704 | 0.89 | LMNA (0.41) | POLBKDRLMNATP53TDP1 | |
| SCHEMBL2179365 | 0.86 | LMNA (0.42) | NPC1RAB9AKDRMEN1KMT2A | |
| SCHEMBL2179560 | 0.85 | NPC1 (0.51) | NPC1RAB9APOLBKDRCASP3 | |
| SCHEMBL2178689 | 0.83 | S1PR1 (0.44) | LMNATP53S1PR1 | |
| SCHEMBL2365142 | 0.81 | AKR1C3 (0.44) | NPC1RAB9ALMNATP53 | |
| SCHEMBL2365140 | 0.81 | AKR1C3 (0.44) | NPC1RAB9ALMNATP53 | |
| SCHEMBL2181058 | 0.81 | LMNA (0.42) | NPC1RAB9APOLBCASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | claimed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |