Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | SDCBP | O00560 | 5/20 | 0.38 |
| ▸ | SDC2 | P34741 | 5/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365140 | 1.00 | AKR1C3 (0.44) | AKR1C3AKR1C2LMNATP53THRB | |
| SCHEMBL2181058 | 0.90 | LMNA (0.42) | AKR1C3AKR1C2LMNATP53THRB | |
| SCHEMBL2365141 | 0.86 | AKR1C3 (0.46) | AKR1C3AKR1C2LMNATP53THRB | |
| SCHEMBL2178689 | 0.84 | S1PR1 (0.44) | LMNATP53 | |
| SCHEMBL2181367 | 0.83 | AKR1C3 (0.44) | AKR1C3AKR1C2LMNATP53SDCBP | |
| SCHEMBL13719612 | 0.83 | AKR1C3 (0.44) | AKR1C3AKR1C2LMNATP53SDCBP | |
| SCHEMBL2178455 | 0.82 | LMNA (0.40) | LMNATP53THRBGAAATM | |
| SCHEMBL2179704 | 0.82 | LMNA (0.41) | LMNATP53THRBSDCBPSDC2 | |
| SCHEMBL2179365 | 0.82 | LMNA (0.42) | LMNATP53THRBGAAATM | |
| SCHEMBL2179328 | 0.81 | NPC1 (0.41) | LMNATP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |