SCHEMBL21794010

SCHEMBL21794010

CN(F)c1cnc(SNc2cccc(F)n2)cc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 7/20 0.39
SCN8A Q9UQD0 7/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21793967 0.77 SCN1A (0.70) SCN1ASCN8A
SCHEMBL21794014 0.76 SCN1A (0.71) SCN1ASCN8A
SCHEMBL19634191 0.69 SCN1A (0.35) SCN1ASCN8A
SCHEMBL21794018 0.67 SCN1A (0.37) SCN1ASCN8A
SCHEMBL23770799 0.64 XPO1 (0.43)
SCHEMBL21793965 0.62 SCN1A (0.33) SCN1ASCN8A
SCHEMBL21794024 0.60 GRM5 (0.33) SCN1ASCN8A
SCHEMBL21783512 0.60 SCN1A (0.32) SCN1ASCN8A
SCHEMBL25083839 0.58 FFAR2 (0.37)
SCHEMBL21793939 0.58 SCN1A (0.34) SCN1ASCN8A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020047312-A1 HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS XENON PHARMACEUTICALS INC. (CA) 2020-03-05 WO disclosed