Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 6/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.31 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.31 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.30 |
| ▸ | GABRP | O00591 | 2/20 | 0.30 |
| ▸ | GABRD | O14764 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14771690 | 0.78 | GRIK1 (0.38) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL16018408 | 0.78 | GABRP (0.36) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL16024166 | 0.78 | ALDH1A1 (0.43) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL33273 | 0.78 | FFAR3 (0.43) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL21690060 | 0.78 | SLC7A5 (0.58) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL21577845 | 0.78 | SLC7A5 (0.58) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL21345146 | 0.78 | GRIK1 (0.38) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL21345666 | 0.78 | FFAR3 (0.43) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL12368601 | 0.78 | ALDH1A1 (0.36) | GRIK1GRIA4GRIK3GRIK5SLC7A5 | |
| SCHEMBL16359636 | 0.78 | FFAR3 (0.43) | GRIK1GRIA4GRIK3GRIK5SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2023-07-04 | — | — | US | disclosed |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | ALCON INC. (CH) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | GRK1, TNK2, CYP11B2 | GRIK1 379/4885GRIA4 1851/4885GRIK3 440/4885 |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | GRIK1 379/4885GRIA4 1851/4885GRIK3 440/4885 |
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | GRIK1 379/4885GRIA4 1851/4885GRIK3 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.