SCHEMBL2179610

SCHEMBL2179610

CC(=O)N1CCCC1C(=O)Nc1ccc(-c2nnc(-c3ccc(NC(=O)[C@@H]4CCCN4C(=O)Cc4cccs4)cc3)o2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.52
MEN1 O00255 5/20 0.52
KMT2A Q03164 5/20 0.52
HPGD P15428 4/20 0.52
POLB P06746 3/20 0.52
XBP1 P17861 1/20 0.52
MAPK1 P28482 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
KDM4E B2RXH2 4/20 0.48
HTT P42858 3/20 0.48
RAB9A P51151 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
SMN1; SMN2 Q16637 3/20 0.47
NPSR1 Q6W5P4 2/20 0.43
MAPT P10636 2/20 0.43
HCRTR1 O43613 1/20 0.43
HCRTR2 O43614 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12488611 1.00 ALDH1A1 (0.52) ALDH1A1MEN1KMT2AHPGDPOLB
SCHEMBL14648164 0.95 ALDH1A1 (0.54) ALDH1A1MEN1KMT2AHPGDPOLB
SCHEMBL2196617 0.95 ALDH1A1 (0.54) ALDH1A1MEN1KMT2AHPGDPOLB
SCHEMBL2175697 0.86 ALDH1A1 (0.50) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL12489099 0.86 ALDH1A1 (0.50) ALDH1A1MEN1KMT2AHPGDKDM4E
SCHEMBL12488451 0.86 ALDH1A1 (0.45) ALDH1A1MEN1KMT2AHPGDPOLB
SCHEMBL2194905 0.86 ALDH1A1 (0.51) ALDH1A1MEN1KMT2AHPGDMAPK1
SCHEMBL845304 0.85 MAPK1 (0.52) ALDH1A1MEN1KMT2APOLBMAPK1
SCHEMBL14648250 0.85 ALDH1A1 (0.44) ALDH1A1MEN1KMT2AHPGDPOLB
SCHEMBL27879648 0.84 ALDH1A1 (0.42) ALDH1A1MEN1KMT2AHPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011082077-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-07-07 WO claimed