Sugi Predict

Sugi Predict / Compounds / SCHEMBL2179677

SCHEMBL2179677

SCHEMBL2179677

CC(C)C(C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4cccc(Oc5ccccc5)c4)cc3)cc2C1=O

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ FABP1 P07148 6/20 0.45
▸ PGR P06401 2/20 0.45
▸ FFAR1 O14842 1/20 0.44
▸ MMP2 P08253 1/20 0.44
▸ MEN1 O00255 3/20 0.43
▸ KMT2A Q03164 3/20 0.43
▸ CASP3 P42574 1/20 0.43
▸ SENP8 Q96LD8 1/20 0.43
▸ SENP7 Q9BQF6 1/20 0.43
▸ SENP6 Q9GZR1 1/20 0.43
▸ POLB P06746 1/20 0.42
▸ MCHR1 Q99705 1/20 0.42
▸ SDCBP O00560 1/20 0.42
▸ SDC2 P34741 1/20 0.42
▸ AR P10275 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13718946 1.00 LMNA (0.47) LMNATP53FABP1PGRFFAR1
SCHEMBL2177289 0.93 LMNA (0.48) LMNATP53FABP1PGRFFAR1
SCHEMBL2179965 0.93 LMNA (0.51) LMNATP53PGRCASP3SENP8
SCHEMBL2179971 0.93 LMNA (0.51) LMNATP53PGRCASP3SENP8
SCHEMBL2179317 0.90 LMNA (0.49) LMNATP53MEN1KMT2ASDCBP
SCHEMBL2179321 0.90 LMNA (0.49) LMNATP53MEN1KMT2ASDCBP
SCHEMBL2179239 0.88 LMNA (0.53) LMNATP53SDCBPSDC2
SCHEMBL2178235 0.88 LMNA (0.53) LMNATP53SDCBPSDC2
SCHEMBL13719015 0.87 LMNA (0.48) LMNATP53MCHR1SDCBPSDC2
SCHEMBL2178118 0.87 LMNA (0.48) LMNATP53MCHR1SDCBPSDC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US claimed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US claimed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP claimed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO claimed
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US disclosed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US disclosed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP disclosed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE DGAT1, DGAT2, LCAT LMNA 2193/4885TP53 2093/4885FABP1 149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.