Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | FLT1 | P17948 | 8/20 | 0.34 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | PLK4 | O00444 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | LYN | P07948 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | FLT4 | P35916 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | FRK | P42685 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.34 |
| ▸ | BLK | P51451 | 3/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.34 |
| ▸ | NEK2 | P51955 | 3/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177083 | 0.84 | RIPK1 (0.39) | RIPK1AURKAFLT1KDRPLK4 | |
| SCHEMBL12409623 | 0.81 | RIPK1 (0.40) | RIPK1AURKAFLT1KDRPLK4 | |
| SCHEMBL2177094 | 0.80 | RIPK1 (0.38) | RIPK1AURKAFLT1KDRPLK4 | |
| SCHEMBL2177474 | 0.78 | KDR (0.47) | RIPK1FLT1KDRPLK4ROCK2 | |
| SCHEMBL2177086 | 0.77 | RIPK1 (0.38) | RIPK1AURKAFLT1KDRPLK4 | |
| SCHEMBL2181805 | 0.76 | RIPK1 (0.38) | RIPK1AURKAFLT1KDRPLK4 | |
| SCHEMBL2179721 | 0.73 | KDR (0.47) | RIPK1FLT1KDRPLK4ROCK2 | |
| SCHEMBL2181801 | 0.70 | RIPK1 (0.38) | RIPK1AURKAFLT1KDRPLK4 | |
| SCHEMBL3158751 | 0.70 | KDR (0.57) | FLT1KDRPLK4ROCK2MAP4K4 | |
| SCHEMBL12409621 | 0.70 | KDR (0.47) | RIPK1FLT1KDRPLK4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166163-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166163-A1 | SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF | DPYD, TPMT, TYMP | RIPK1 4127/4885AURKA 2987/4885FLT1 475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.