Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 5/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21798637 | 0.83 | HDAC1 (0.57) | HDAC1HDAC6AOX1KDM4EKMT2A | |
| SCHEMBL21798644 | 0.82 | AOX1 (0.54) | HDAC1HDAC6AOX1KDM4EKMT2A | |
| SCHEMBL21798690 | 0.80 | MAPT (0.46) | KDM4EKMT2AMAPTMEN1GLA | |
| SCHEMBL21798642 | 0.80 | HDAC1 (0.53) | HDAC1HDAC6AOX1KDM4EKMT2A | |
| SCHEMBL21798688 | 0.79 | HDAC1 (0.45) | HDAC1HDAC6AOX1KDM4EKMT2A | |
| SCHEMBL8652717 | 0.77 | AOX1 (0.59) | HDAC1HDAC6AOX1KDM4ERAD52 | |
| SCHEMBL8652716 | 0.75 | HDAC1 (0.45) | HDAC1HDAC6AOX1KDM4EMAPT | |
| SCHEMBL7568845 | 0.74 | HDAC1 (0.67) | HDAC1HDAC6AOX1KDM4EKMT2A | |
| SCHEMBL21798685 | 0.74 | HDAC1 (0.51) | HDAC1HDAC6AOX1KDM4EKMT2A | |
| SCHEMBL105276 | 0.74 | AOX1 (0.78) | HDAC1HDAC6AOX1KDM4ERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046687-B2 | Polycyclic amide compound, preparation process and use thereof | HEBEI GRANDIOS PHARMA CO., LTD. | 2021-06-29 | — | — | US | disclosed |
| US-20200079771-A1 | Novel Polycyclic Amide Compound, Preparation Process And Use Thereof | HEBEI GRANDIOS PHARMA CO., LTD. (CN) | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079771-A1 | Novel Polycyclic Amide Compound, Preparation Process And Use Thereof | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-0, UACA | HDAC1 34/4885HDAC6 139/4885AOX1 453/4885 |
| US-11046687-B2 | Polycyclic amide compound, preparation process and use thereof | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, UACA, H1-0 | HDAC1 30/4885HDAC6 144/4885AOX1 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.