Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18134700 | 1.00 | POLB (0.44) | POLBHTTMAPTCHRNB2CHRNA4 | |
| SCHEMBL18502527 | 0.95 | MAPT (0.43) | POLBHTTMAPTCHRNB2CHRNA4 | |
| SCHEMBL18502526 | 0.95 | MAPT (0.43) | POLBHTTMAPTCHRNB2CHRNA4 | |
| SCHEMBL10244794 | 0.84 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNA7CHRNA5CYP1A2 | |
| SCHEMBL15745587 | 0.83 | POLB (0.49) | POLBHTTMAPTCHRNB2CHRNA4 | |
| SCHEMBL26184790 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA7CHRNA5CYP1A2 | |
| SCHEMBL1033553 | 0.79 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA7CHRNA5CYP1A2 | |
| SCHEMBL336170 | 0.79 | CHRNB2 (0.45) | POLBCHRNB2CHRNA4CHRNA7CHRNA5 | |
| SCHEMBL336171 | 0.79 | CHRNB2 (0.45) | POLBCHRNB2CHRNA4CHRNA7CHRNA5 | |
| SCHEMBL15745596 | 0.78 | MAPT (0.49) | POLBHTTMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279852-B | Triazolo-pyrimidine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-111635408-B | Triazolo-pyrimidine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-07-22 | — | — | CN | disclosed |
| EP-3849983-A1 | TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020052631-A1 | TRIAZOLO-PYRIMIDINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-03-19 | — | — | WO | disclosed |