Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | ADK | P55263 | 5/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178876 | 0.87 | RET (0.40) | RETADKSLC29A1MEN1NR2F2 | |
| SCHEMBL21801527 | 0.79 | — | — | |
| SCHEMBL21801405 | 0.78 | L3MBTL1 (0.35) | RETMEN1KMT2A | |
| SCHEMBL22037128 | 0.75 | MEN1 (0.41) | RETADKSLC29A1MEN1NR2F2 | |
| SCHEMBL21178731 | 0.73 | ADK (0.31) | ADK | |
| SCHEMBL18341927 | 0.69 | RET (0.37) | RETADKMEN1NR2F2KMT2A | |
| SCHEMBL21801349 | 0.67 | RET (0.51) | RET | |
| SCHEMBL30893381 | 0.63 | MEN1 (0.41) | RETADKMEN1NR2F2KMT2A | |
| SCHEMBL3632947 | 0.61 | ALDH1A1 (0.35) | — | |
| SCHEMBL407871 | 0.61 | ADK (0.46) | RETADKSLC29A1MEN1NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849986-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020055672-A1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2020-03-19 | — | — | WO | disclosed |