SCHEMBL21801941

SCHEMBL21801941

Nc1cnc2c(c1)C(=O)N1C[C@@H](F)C[C@@H]1CO2

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALPL P05186 17/20 0.51
NTRK1 P04629 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21802108 0.85 ALPL (0.52) ALPL
SCHEMBL21801979 0.85 ALPL (0.52) ALPL
SCHEMBL30538759 0.85 ALPL (0.52) ALPL
SCHEMBL30538722 0.83 ALPL (0.54) ALPL
SCHEMBL21802103 0.81 ALPL (0.48) ALPL
SCHEMBL21802039 0.81 ALPL (0.47) ALPL
SCHEMBL21802084 0.80 ALPL (0.54) ALPL
SCHEMBL21801939 0.80 ALPL (0.46) ALPL
SCHEMBL30538725 0.79 ALPL (0.58) ALPL
SCHEMBL21801973 0.78 ALPL (0.49) ALPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3559007-B1 SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY DAIICHI SANKYO CO LTD (JP) 2023-08-16 EP disclosed
US-11046710-B2 Sulfonamide compounds DAIICHI SANKYO COMPANY, LIMITED (JP) 2021-06-29 US disclosed
US-11014939-B2 2021-05-25 US disclosed
US-20200087321-A1 SULFONAMIDE COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2020-03-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200087321-A1 SULFONAMIDE COMPOUNDS ALPI, ASAH2, STS ALPL 7/4885NTRK1 2974/4885
US-11014939-B2 ALPI, ALPP, ACER2 ALPL 5/4885NTRK1 2968/4885
US-11046710-B2 Sulfonamide compounds ALPI, ASAH2, STS ALPL 7/4885NTRK1 2974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.