Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179263 | 0.92 | DGAT1 (0.44) | LMNATP53THRBDGAT1MEN1 | |
| SCHEMBL13719602 | 0.92 | DGAT1 (0.44) | LMNATP53THRBDGAT1MEN1 | |
| SCHEMBL2224009 | 0.85 | HTR2A (0.40) | LMNATP53THRBDGAT1MEN1 | |
| SCHEMBL2180394 | 0.85 | HTR2A (0.40) | LMNATP53THRBDGAT1MEN1 | |
| SCHEMBL2179365 | 0.83 | LMNA (0.42) | LMNATP53THRBMEN1NPC1 | |
| SCHEMBL2223220 | 0.83 | LMNA (0.47) | LMNATP53THRBMEN1KMT2A | |
| SCHEMBL2180501 | 0.83 | LMNA (0.47) | LMNATP53THRBMEN1KMT2A | |
| SCHEMBL13718751 | 0.80 | DGAT1 (0.51) | LMNATP53THRBDGAT1CSGALNACT1 | |
| SCHEMBL2176697 | 0.80 | DGAT1 (0.51) | LMNATP53THRBDGAT1CSGALNACT1 | |
| SCHEMBL2176926 | 0.77 | DGAT1 (0.43) | LMNATP53THRBDGAT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | claimed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |