SCHEMBL21804702

SCHEMBL21804702

CN(C[C@H](C(=O)O)c1cccc(Cl)c1)C(=O)OC(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
ITGB1 P05556 1/20 0.44
ITGA4 P13612 1/20 0.44
AOC3 Q16853 2/20 0.40
RIPK1 Q13546 1/20 0.38
CCKAR P32238 2/20 0.38
CTSL P07711 1/20 0.38
SLC6A4 P31645 4/20 0.37
HTR2C P28335 1/20 0.37
SLC6A2 P23975 3/20 0.37
AURKA O14965 2/20 0.36
RPS6KB1 P23443 2/20 0.36
KDM4E B2RXH2 1/20 0.36
BCHE P06276 1/20 0.36
ACHE P22303 1/20 0.36
MARK4 Q96L34 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21804705 1.00 MEN1 (0.48) MEN1KMT2AITGB1ITGA4AOC3
SCHEMBL21807150 0.88 AOC3 (0.41) MEN1KMT2AITGB1ITGA4AOC3
SCHEMBL23699426 0.86 CYP2C19 (0.41) MEN1KMT2AITGB1ITGA4SLC6A4
SCHEMBL31622222 0.85 POLB (0.44) MEN1KMT2AITGB1ITGA4AOC3
SCHEMBL25251768 0.84 AOC3 (0.45) AOC3CCKARSLC6A4SLC6A2AURKA
SCHEMBL25292817 0.83 APP (0.41) ITGB1ITGA4SLC6A4HTR2CSLC6A2
SCHEMBL23699188 0.83 RIPK1 (0.37) MEN1KMT2AITGB1ITGA4AOC3
SCHEMBL23699185 0.83 RIPK1 (0.37) MEN1KMT2AITGB1ITGA4AOC3
SCHEMBL499093 0.82 AOC3 (0.42) ITGB1ITGA4AOC3RIPK1SLC6A4
SCHEMBL499618 0.82 AOC3 (0.42) ITGB1ITGA4AOC3RIPK1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230065368-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2023-03-02 US disclosed
US-20230065368-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2023-03-02 US disclosed
US-20210346356-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2021-11-11 US disclosed
US-20210346356-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2021-11-11 US disclosed
EP-3852790-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X Forma Therapeutics, Inc. (US) 2021-07-28 EP disclosed
EP-3852792-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X Forma Therapeutics, Inc. (US) 2021-07-28 EP disclosed
CN-113164571-A Inhibition of ubiquitin-specific peptidase 9X 福马治疗股份有限公司 2021-07-23 CN disclosed
WO-2021055668-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2021-03-25 WO disclosed
WO-2021055668-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2021-03-25 WO disclosed
WO-2020191022-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-09-24 WO disclosed
WO-2020191022-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-09-24 WO disclosed
WO-2020061252-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-03-26 WO disclosed
WO-2020061252-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-03-26 WO disclosed
WO-2020061261-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-03-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210346356-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X USP9X, RBX1, USP19 MEN1 3145/4885KMT2A 550/4885ITGB1 3798/4885
US-20230065368-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X USP9X, USP19, USP39 MEN1 3166/4885KMT2A 1040/4885ITGB1 4722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.