Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.55 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 8/20 | 0.63 |
| ▸ | HTR1D | P28221 | 5/20 | 0.63 |
| ▸ | HTR6 | P50406 | 10/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2182475 | 1.00 | HTR1B (0.63) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| Oxalic Acid SCHEMBL2727283 | 0.94 | HTR1B (0.68) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| Oxalic Acid SCHEMBL2725284 | 0.94 | HTR1B (0.68) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| SCHEMBL697582 | 0.90 | HTR1B (0.76) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| SCHEMBL2182107 | 0.90 | HTR1B (0.76) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| SCHEMBL772429 | 0.90 | HTR1B (0.76) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| SCHEMBL29827195 | 0.90 | HTR1B (0.76) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| Fumaric Acid SCHEMBL7834732 | 0.82 | HTR1B (0.86) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| Fumaric Acid SCHEMBL7834729 | 0.82 | HTR1B (0.86) | HTR1BHTR1DHTR6HTR1ACHRM2 | |
| Fumaric Acid SCHEMBL7834727 | 0.82 | HTR1B (0.86) | HTR1BHTR1DHTR6HTR1ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166364-A1 | SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166364-A1 | SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | TMPRSS15, PEPD, DPP9 | CHRM2 2568/4885SLC6A2 52/4885HTR1B 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.