Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.76 |
| ▸ | HTR1D | P28221 | 5/20 | 0.76 |
| ▸ | HTR1A | P08908 | 3/20 | 0.71 |
| ▸ | HTR6 | P50406 | 10/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697582 | 1.00 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL772429 | 1.00 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL29827195 | 1.00 | HTR1B (0.76) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| Oxalic Acid SCHEMBL2727283 | 0.94 | HTR1B (0.68) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| Oxalic Acid SCHEMBL2725284 | 0.94 | HTR1B (0.68) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| Fumaric Acid SCHEMBL2180504 | 0.90 | HTR1B (0.63) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| Fumaric Acid SCHEMBL2182475 | 0.90 | HTR1B (0.63) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8888890 | 0.87 | HTR1B (0.60) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8508432 | 0.86 | HTR1B (1.00) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8208343 | 0.86 | HTR1B (1.00) | HTR1BHTR1DHTR1AHTR6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421853-B1 | SYNTHESIS OF 3-{[(2R)-1-METHYLPYRROLIDIN-2-YL]METHYL}-5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | ITALIANA SINT SPA (IT) | 2013-07-24 | — | — | EP | disclosed |
| US-8426612-B2 | Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2013-04-23 | — | — | US | disclosed |
| US-20120071669-A1 | PROCESS FOR PREPARATION OF ELETRIPTAN AND SALT THEREOF | USV Limited B.S.D. Mar (IN) | 2012-03-22 | — | — | US | disclosed |
| US-20110166364-A1 | SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2011-07-07 | — | — | US | disclosed |
| CN-1289479-C | As 5-HT1D5-ring indole compounds of receptor ligands | ALLELIX BIOPHARMA (CA) | 2006-12-13 | — | — | CN | disclosed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| EP-1098896-B1 | 5-BICYCLOINDOLE COMPOUNDS | NPS ALLELIX CORP (CA) | 2003-06-25 | — | — | EP | disclosed |
| CN-1245491-A | 5-cyclo indole compounds as 5-HT receptor ligands | ALLELIX BIOPHARMA (CA) | 2000-02-23 | — | — | CN | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071669-A1 | PROCESS FOR PREPARATION OF ELETRIPTAN AND SALT THEREOF | HTR3C, SLC6A4, HTR3A | HTR1B 21/4885HTR1D 26/4885HTR1A 12/4885 |
| US-20110166364-A1 | SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE | TMPRSS15, PEPD, DPP9 | HTR1B 254/4885HTR1D 137/4885HTR1A 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.