Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 2/20 | 0.31 |
| ▸ | NSD2 | O96028 | 2/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.31 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8112420 | 0.80 | TDP2 (0.39) | IDO1TDP2NSD2PAX8TGM2 | |
| SCHEMBL16380549 | 0.79 | MKNK1 (0.38) | MKNK1MKNK2GAA | |
| SCHEMBL28388519 | 0.79 | PDE5A (0.34) | IDO1TDP2NSD2PAX8ABL1 | |
| SCHEMBL7212308 | 0.78 | PRMT5 (0.35) | AKT1 | |
| SCHEMBL12615990 | 0.76 | ALDH1A1 (0.38) | IDO1MEN1KMT2AGAA | |
| SCHEMBL2627823 | 0.76 | TNKS2 (0.34) | — | |
| SCHEMBL17478606 | 0.76 | MKNK1 (0.38) | MKNK1MKNK2CDK2THRBBLM | |
| SCHEMBL18226941 | 0.76 | CA1 (0.34) | TDP2NSD2PAX8ABL1PLCG1 | |
| SCHEMBL30940314 | 0.76 | ALDH1A1 (0.52) | IDO1TDP1GAA | |
| SCHEMBL3277728 | 0.76 | ALDH1A1 (0.52) | IDO1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3852736-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | Metacrine, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061118-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| WO-2020061117-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2020-03-26 | — | — | WO | disclosed |