Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 6/20 | 0.48 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 10/20 | 0.36 |
| ▸ | HTR2A | P28223 | 9/20 | 0.36 |
| ▸ | HTR2B | P41595 | 9/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29329813 | 0.86 | TRPC5 (0.47) | TRPC5TRPC4HTR2CHTR2AHTR2B | |
| SCHEMBL21832182 | 0.80 | TRPC5 (0.43) | TRPC5TRPC4HTR2CHTR2AHTR2B | |
| SCHEMBL21807544 | 0.78 | TRPC5 (0.40) | TRPC5TRPC4HTR2CHTR2AHTR2B | |
| SCHEMBL21807225 | 0.77 | TRPC5 (0.55) | TRPC5TRPC4 | |
| SCHEMBL21807389 | 0.75 | TRPC5 (0.43) | TRPC5TRPC4RBP4TTRAURKA | |
| SCHEMBL21807664 | 0.72 | AURKA (0.39) | TRPC5TRPC4AURKAHTR1ASLC6A2 | |
| SCHEMBL21807194 | 0.71 | HTR2C (0.41) | TRPC5HTR2CHTR2AHTR2BHTR1A | |
| SCHEMBL21807564 | 0.71 | TRPC5 (0.42) | TRPC5TRPC4HTR2CHTR2AHTR2B | |
| SCHEMBL21807239 | 0.69 | HTR1A (0.42) | TRPC5HTR2CHTR2AHTR2BVCP | |
| SCHEMBL29329894 | 0.68 | HTR2C (0.37) | TRPC5HTR2CHTR2AHTR2BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941475-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3852533-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020191056-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
| WO-2020061162-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2020-03-26 | — | — | WO | disclosed |