Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 5/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2182724 | 0.97 | PCSK9 (0.39) | PCSK9DCTPP1ADORA2BPOLBTP53 | |
| SCHEMBL3262395 | 0.90 | DCTPP1 (0.34) | PCSK9DCTPP1ADORA2BPOLBTP53 | |
| SCHEMBL2182311 | 0.89 | DCTPP1 (0.35) | PCSK9DCTPP1ADORA2BPOLBTP53 | |
| SCHEMBL2181412 | 0.88 | RAD52 (0.38) | PCSK9DCTPP1GAASMN1; SMN2KDM4E | |
| SCHEMBL2182871 | 0.88 | DCTPP1 (0.34) | PCSK9DCTPP1ADORA2BPOLBTP53 | |
| SCHEMBL2181236 | 0.87 | DCTPP1 (0.35) | PCSK9DCTPP1ADORA2BPOLBTP53 | |
| SCHEMBL2182596 | 0.87 | ALDH1A1 (0.37) | PCSK9DCTPP1POLBTP53SMN1; SMN2 | |
| SCHEMBL2178907 | 0.86 | PCSK9 (0.41) | PCSK9DCTPP1POLBTP53SMN1; SMN2 | |
| SCHEMBL2182270 | 0.85 | ALDH1A1 (0.37) | DCTPP1POLBTP53GAASMN1; SMN2 | |
| SCHEMBL2181518 | 0.84 | SCN5A (0.42) | DCTPP1ADORA2BSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | DPYD, TYMP, DHFR | PCSK9 1993/4885DCTPP1 49/4885ADORA2B 1389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.