Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CPB1 | P15086 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 5/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30687256 | 0.89 | ALDH1A1 (0.64) | ALDH1A1GAATSHRHSD11B1CTSL | |
| SCHEMBL26986498 | 0.89 | ALDH1A1 (0.64) | ALDH1A1GAATSHRHSD11B1CTSL | |
| SCHEMBL2902121 | 0.89 | ALDH1A1 (0.64) | ALDH1A1GAATSHRHSD11B1CTSL | |
| SCHEMBL7948452 | 0.87 | HSD11B1 (0.48) | ALDH1A1GAACPB1TSHRHSD11B1 | |
| SCHEMBL8097829 | 0.87 | HSD11B1 (0.48) | ALDH1A1GAACPB1TSHRHSD11B1 | |
| SCHEMBL25438608 | 0.87 | HSD11B1 (0.48) | ALDH1A1GAACPB1TSHRHSD11B1 | |
| SCHEMBL13630910 | 0.87 | HSD11B1 (0.48) | ALDH1A1GAACPB1TSHRHSD11B1 | |
| SCHEMBL13434301 | 0.87 | HSD11B1 (0.48) | ALDH1A1GAACPB1TSHRHSD11B1 | |
| SCHEMBL8097832 | 0.87 | HSD11B1 (0.48) | ALDH1A1GAACPB1TSHRHSD11B1 | |
| SCHEMBL30736145 | 0.87 | HSD11B1 (0.48) | ALDH1A1GAACPB1TSHRHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849664-A1 | PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020056089-A1 | PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2020-03-19 | — | — | WO | disclosed |