Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863 | 0.88 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1CHRM5CHRM3KDM4E | |
| Hydrochloric Acid SCHEMBL963162 | 0.86 | ALDH1A1 (0.54) | SIGMAR1ALDH1A1CHRM5CHRM3DRD2 | |
| Piperazine SCHEMBL28845954 | 0.86 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1CHRM5CHRM3DRD2 | |
| Hydrochloric Acid SCHEMBL17271878 | 0.86 | ALDH1A1 (0.54) | SIGMAR1ALDH1A1CHRM5CHRM3DRD2 | |
| SCHEMBL2011012 | 0.81 | SIGMAR1 (0.64) | SIGMAR1ALDH1A1CHRM5CHRM3CHRM2 | |
| Trifluoroacetic Acid SCHEMBL6897031 | 0.81 | SIGMAR1 (0.44) | SIGMAR1CHRM5CHRM3PKMHRH4 | |
| Hydrochloric Acid SCHEMBL2009563 | 0.80 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1CHRM5CHRM3CHRM2 | |
| Trifluoroacetic Acid SCHEMBL28555170 | 0.78 | KDM4E (0.44) | SIGMAR1CHRM5CHRM3PKMHRH4 | |
| Trifluoroacetic Acid SCHEMBL3809378 | 0.77 | ALDH1A1 (0.39) | SIGMAR1ALDH1A1CHRM5CHRM3PKM | |
| Trifluoroacetic Acid SCHEMBL6474887 | 0.75 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1CHRM5CHRM3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640248-B1 | AMINOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF | BEIJING ADAMADLE BIOTECHNOLOGY LLC (CN) | 2023-08-23 | — | — | EP | disclosed |
| US-11352352-B2 | Aminopyrimidine compound, preparation method therefor and use thereof | Beijing Adamadle Biotechnology Limited Liability Company (CN) | 2022-06-07 | — | — | US | disclosed |
| EP-3640248-A1 | AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Beijing Adamadle Biotechnology Limited Liability Company (CN) | 2020-04-22 | — | — | EP | disclosed |
| US-20200087296-A1 | AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Beijing Adamadle Biotechnology Limited Liability Company (CN) | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200087296-A1 | AMINOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | WEE1, WEE2, EGFR | SIGMAR1 3778/4885ALDH1A1 1646/4885CHRM5 4849/4885 |
| US-11352352-B2 | Aminopyrimidine compound, preparation method therefor and use thereof | WEE1, WEE2, EGFR | SIGMAR1 3778/4885ALDH1A1 1646/4885CHRM5 4849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.