Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20946422 | 0.91 | SIGMAR1 (0.63) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| SCHEMBL1547058 | 0.91 | SIGMAR1 (0.63) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| SCHEMBL19640159 | 0.89 | SIGMAR1 (0.61) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| Hydrochloric Acid SCHEMBL26129894 | 0.89 | SIGMAR1 (0.61) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| Hydrochloric Acid SCHEMBL2009825 | 0.89 | SIGMAR1 (0.61) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| SCHEMBL22883481 | 0.81 | SIGMAR1 (0.52) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| SCHEMBL22883386 | 0.79 | SIGMAR1 (0.51) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| Trifluoroacetic Acid SCHEMBL6897031 | 0.79 | SIGMAR1 (0.44) | SIGMAR1CHRM5CHRM3HRH4 | |
| SCHEMBL20661394 | 0.76 | SIGMAR1 (0.48) | SIGMAR1CHRM5CHRM3ALDH1A1CACNA1H | |
| Trifluoroacetic Acid SCHEMBL5269618 | 0.76 | SIGMAR1 (0.45) | SIGMAR1CHRM5CHRM3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962911-B2 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2005-11-08 | — | — | US | disclosed |
| EP-1257553-B1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO LTD (KR) | 2004-05-26 | — | — | EP | disclosed |
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | SK CHEMICALS CO., LTD. (KR) | 2003-09-11 | — | — | US | disclosed |
| EP-1257553-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK Chemicals Co., Ltd. (KR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060825-A1 | PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE | SK CHEMICALS CO., LTD. (KR) | 2001-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171361-A1 | Pyrrolopyrimidinone derivatives, process of preparation and use | CYP2C19, DHPS, SDHA | SIGMAR1 4345/4885CHRM5 4150/4885CHRM3 4351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.