⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27682287 | 0.81 | CES2 (0.39) | — | |
| SCHEMBL568600 | 0.79 | — | — | |
| SCHEMBL1674356 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL9626058 | 0.77 | DAO (0.54) | — | |
| SCHEMBL1820040 | 0.77 | — | — | |
| SCHEMBL1771714 | 0.74 | — | — | |
| SCHEMBL16933079 | 0.74 | GSK3B (0.50) | — | |
| SCHEMBL11001917 | 0.73 | — | — | |
| SCHEMBL365156 | 0.72 | CA1 (0.45) | — | |
| SCHEMBL8317718 | 0.72 | SMN1; SMN2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102164908-B | Selective estrogen repector modulator for the treatment of osteoarthritis | LILLY CO ELI | 2013-08-28 | — | — | CN | disclosed |
| US-8476300-B2 | Selective estrogen receptor modulator for the treatment of osteoarthritis | ELI LILLY AND COMPANY (US) | 2013-07-02 | — | — | US | disclosed |
| CN-102164908-A | Selective estrogen repector modulator for the treatment of osteoarthritis | LILLY CO ELI | 2011-08-24 | — | — | CN | disclosed |
| EP-2342189-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF OSTEOARTHRITIS | ELI LILLY AND COMPANY (US) | 2011-07-13 | — | — | EP | disclosed |
| US-20110166182-A1 | Selective Estrogen Receptor Modulator for the Treatment of Osteoarthritis | ELI LILLY AND COMPANY (US) | 2011-07-07 | — | — | US | disclosed |
| WO-2010036497-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR | ELI LILLY AND COMPANY (US) | 2010-04-01 | — | — | WO | disclosed |
| EP-0186252-B1 | USE OF THIOPHENE COMPOUNDS FOR THE MANUFACTURE OF A MEDICAMENT AGAINST TUMOURS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1992-04-01 | — | — | EP | disclosed |
| US-4767758-A | RADIOSENSITIZING CELLS; BLOCKING REACTION OF OXYGEN RADICALS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1988-08-30 | — | — | US | disclosed |
| EP-0186252-A2 | Use of thiophene compounds for the manufacture of a medicament against tumours | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1986-07-02 | — | — | EP | disclosed |