Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | RPA1 | P27694 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18865628 | 0.83 | CA9 (0.50) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20788373 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2PPP1CAALDH1A1NPY5RRPA1 | |
| SCHEMBL1259296 | 0.81 | ALDH1A1 (0.64) | PPP1CAALDH1A1MAPK1NPY5RRPA1 | |
| SCHEMBL21821553 | 0.80 | SMPD1 (0.49) | SMN1; SMN2PPP1CAALDH1A1MAPK1NPY5R | |
| SCHEMBL2865749 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2PPP1CAALDH1A1MAPK1NPY5R | |
| SCHEMBL6052304 | 0.80 | KMT2A (0.62) | SMN1; SMN2PPP1CAALDH1A1MAPK1NPY5R | |
| SCHEMBL27717194 | 0.79 | RPA1 (0.74) | SMN1; SMN2PPP1CAALDH1A1RPA1MEN1 | |
| SCHEMBL3117397 | 0.78 | PTGS2 (0.58) | SMN1; SMN2KMT2A | |
| SCHEMBL2288170 | 0.78 | MAPT (0.53) | ALDH1A1L3MBTL1MAPTTDP1 | |
| SCHEMBL21821542 | 0.77 | RPA1 (0.55) | SMN1; SMN2PPP1CAALDH1A1MAPK1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3696181-A1 | PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS | Forma Therapeutics, Inc. (US) | 2020-08-19 | — | — | EP | disclosed |
| EP-3377493-B1 | PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-04-08 | — | — | EP | disclosed |