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Sugi Predict / Compounds / SCHEMBL2865749

SCHEMBL2865749

SCHEMBL2865749

Cc1cc(C(=O)O)nn1-c1ccc(Cl)cc1

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.66
▸ PPP1CA P62136 2/20 0.66
▸ RPA1 P27694 4/20 0.66
▸ L3MBTL1 Q9Y468 2/20 0.58
▸ MEN1 O00255 2/20 0.58
▸ KMT2A Q03164 2/20 0.58
▸ ATM Q13315 1/20 0.58
▸ NPY5R Q15761 1/20 0.57
▸ ALDH1A1 P00352 2/20 0.51
▸ MALT1 Q9UDY8 3/20 0.49
▸ NFKB1 P19838 1/20 0.49
▸ NFKB2 Q00653 1/20 0.49
▸ RELA Q04206 1/20 0.49
▸ NOTUM Q6P988 1/20 0.49
▸ MAPK1 P28482 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20788373 0.92 SMN1; SMN2 (0.57) SMN1; SMN2PPP1CARPA1L3MBTL1MEN1
SCHEMBL5678707 0.87 NPY5R (0.53) SMN1; SMN2PPP1CARPA1L3MBTL1MEN1
SCHEMBL15167854 0.86 L3MBTL1 (0.64) SMN1; SMN2PPP1CARPA1L3MBTL1NPY5R
SCHEMBL1259296 0.85 ALDH1A1 (0.64) PPP1CARPA1L3MBTL1MEN1KMT2A
SCHEMBL21821553 0.84 SMPD1 (0.49) SMN1; SMN2PPP1CARPA1L3MBTL1MEN1
SCHEMBL6052304 0.84 KMT2A (0.62) SMN1; SMN2PPP1CARPA1MEN1KMT2A
SCHEMBL17055465 0.83 MALT1 (0.71) SMN1; SMN2PPP1CAMEN1KMT2ANPY5R
SCHEMBL2318841 0.82 RPA1 (0.68) SMN1; SMN2PPP1CARPA1L3MBTL1MEN1
SCHEMBL1831047 0.81 RPA1 (0.68) SMN1; SMN2PPP1CARPA1L3MBTL1NOTUM
SCHEMBL31518945 0.81 RPA1 (0.68) SMN1; SMN2PPP1CARPA1L3MBTL1NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710428-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-25 — — EP disclosed
CN-119591584-A Preparation and application of 1-substituted phenyl-5-methyl-1H-pyrazole-3-carboxamide derivative 河北大学 2025-03-11 — — CN disclosed
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-09-19 — — US disclosed
CN-112204009-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2024-05-07 — — CN disclosed
EP-3452456-B1 BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2023-07-05 — — EP disclosed
CN-109641854-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-02-03 — — CN disclosed
US-10913727-B2 Modulators of the integrated stress pathway ABBVIE INC. (US) 2021-02-09 — — US disclosed
CN-112204009-A Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2021-01-08 — — CN disclosed
US-20200345727-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2020-11-05 — — US disclosed
EP-3710428-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2020-09-23 — — EP disclosed
EP-2227453-B1 HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS VERTEX PHARMA (US) 2016-03-09 — — EP disclosed
US-8519137-B2 Heteroaryl amides useful as inhibitors of voltage-gated sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-08-27 — — US disclosed
EP-2227453-A2 HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS Vertex Pharmaceuticals Incorporated (US) 2010-09-15 — — EP disclosed
WO-2009049180-A2 HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-04-16 — — WO disclosed
US-20090099233-A1 HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED 2009-04-16 — — US disclosed
EP-1620405-A2 PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS Abbott Laboratories (US) 2006-02-01 — — EP disclosed
US-20050020564-A1 Pyrazole-amides and sulfonamides as sodium channel modulators ABBOTT LABORATORIES 2005-01-27 — — US disclosed
WO-2004099154-A2 PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS ABBOTT LABORATORIES (US) 2004-11-18 — — WO disclosed
US-20040220170-A1 Pyrazole-amides and sulfonamides as sodium channel modulators ABBOTT LABORATORIES 2004-11-04 — — US disclosed
CN-1035752-A Plant protectant based on the pyrazole carboxylic acid derivative HOECHST AG (DE) 1989-09-27 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099233-A1 HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS CACNA1B, SCN3A, SCN2A SMN1; SMN2 1406/4885PPP1CA 1728/4885RPA1 4733/4885
US-10913727-B2 Modulators of the integrated stress pathway ATF4, ATF1, DDIT3 SMN1; SMN2 2486/4885PPP1CA 967/4885RPA1 1718/4885
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 SMN1; SMN2 2486/4885PPP1CA 967/4885RPA1 1718/4885
US-20050020564-A1 Pyrazole-amides and sulfonamides as sodium channel modulators SCN3A, KCNN3, TRPV3 SMN1; SMN2 395/4885PPP1CA 494/4885RPA1 4687/4885
US-20040220170-A1 Pyrazole-amides and sulfonamides as sodium channel modulators SCN3A, KCNN3, TRPV3 SMN1; SMN2 395/4885PPP1CA 494/4885RPA1 4687/4885
US-20200345727-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 SMN1; SMN2 2486/4885PPP1CA 967/4885RPA1 1718/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.