Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537937 | 0.85 | CYP11B1 (0.33) | ALDH1A1 | |
| SCHEMBL28376837 | 0.85 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL16955780 | 0.78 | ALDH1A1 (0.30) | ALDH1A1MAPK1 | |
| SCHEMBL10204235 | 0.76 | GABRA1 (0.39) | GABRA1GABRB1ALDH1A1MAPK1TACR1 | |
| SCHEMBL18599186 | 0.76 | TACR1 (0.31) | GABRA1GABRB1TACR1 | |
| SCHEMBL4175801 | 0.74 | TACR1 (0.31) | TACR1 | |
| SCHEMBL31039376 | 0.74 | ALDH1A1 (0.36) | GABRA1GABRB1ALDH1A1MAPK1TACR1 | |
| SCHEMBL17694467 | 0.73 | DHFR (0.39) | ALDH1A1TACR1 | |
| SCHEMBL21974574 | 0.73 | TACR1 (0.30) | TACR1 | |
| SCHEMBL19707538 | 0.72 | GABRA1 (0.37) | GABRA1GABRB1ALDH1A1MAPK1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | GABRA1 948/4885GABRB1 425/4885ALDH1A1 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.