Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | SPOP | O43791 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184325 | 0.96 | NCOA1 (0.44) | MAPK1CYP3A4CYP2D6CYP2C19USP2 | |
| SCHEMBL2180623 | 0.92 | CHRNB2 (0.39) | MAPK1CYP3A4CYP2C19TSHRSMN1; SMN2 | |
| SCHEMBL2181993 | 0.88 | MAPK1 (0.49) | MAPK1USP2MAPTTSHRNCOA1 | |
| SCHEMBL2182625 | 0.87 | CHRNB2 (0.40) | MAPK1CYP3A4CYP2C19TSHRSMN1; SMN2 | |
| SCHEMBL2181482 | 0.86 | SMN1; SMN2 (0.53) | MAPK1NCOA1NCOA3SMN1; SMN2SPOP | |
| SCHEMBL2183111 | 0.86 | ALDH1A1 (0.42) | MAPK1CYP3A4CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL2179399 | 0.85 | ALDH1A1 (0.42) | MAPK1CYP3A4CYP2C19MAPTSMN1; SMN2 | |
| SCHEMBL2182813 | 0.85 | ALDH1A1 (0.42) | MAPK1CYP3A4CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL2183469 | 0.85 | ALDH1A1 (0.41) | MAPK1CYP3A4CYP2C19MAPTSMN1; SMN2 | |
| SCHEMBL2184655 | 0.84 | ALDH1A1 (0.42) | MAPK1CYP3A4CYP2C19MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | DPYD, TYMP, DHFR | MAPK1 3843/4885CYP3A4 613/4885CYP2D6 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.