Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.66 |
| ▸ | TUBB | P07437 | 3/20 | 0.66 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.66 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.66 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.66 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.66 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.66 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.66 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.66 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.66 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.66 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.66 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12414681 | 0.89 | AADAT (0.74) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14441179 | 0.89 | AADAT (0.74) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10690811 | 0.88 | AADAT (0.73) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10753055 | 0.88 | AADAT (0.73) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL2182859 | 0.88 | AADAT (0.73) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10688974 | 0.88 | AADAT (0.73) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10688982 | 0.88 | AADAT (0.73) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9142971 | 0.88 | AADAT (0.78) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9146426 | 0.88 | AADAT (0.78) | AADATKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9484226 | 0.86 | AADAT (0.75) | AADATKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455482-B2 | Substituted pyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-06-04 | — | — | US | disclosed |
| US-8455482-B2 | Substituted pyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-06-04 | — | — | US | disclosed |
| US-8455482-B2 | Substituted pyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-06-04 | — | — | US | disclosed |
| US-7977327-B2 | Substituted pyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977327-B2 | Substituted pyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977327-B2 | Substituted pyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-07-12 | — | — | US | disclosed |
| US-20110166131-A1 | SUBSTITUTED PYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166131-A1 | SUBSTITUTED PYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166131-A1 | SUBSTITUTED PYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20080045520-A1 | Substituted Pyrrolidine Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-02-21 | — | — | US | disclosed |
| US-20080045520-A1 | Substituted Pyrrolidine Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-02-21 | — | — | US | disclosed |
| US-20080045520-A1 | Substituted Pyrrolidine Derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-02-21 | — | — | US | disclosed |
| EP-1757598-A1 | SUBSTITUTED PYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166131-A1 | SUBSTITUTED PYRROLIDINE DERIVATIVE | AQP1, GLUL, GATD3 | AADAT 1159/4885KDM4E 2368/4885ALDH1A1 2627/4885 |
| US-20080045520-A1 | Substituted Pyrrolidine Derivative | QPCT, GMPS, QPCTL | AADAT 1194/4885KDM4E 1998/4885ALDH1A1 2155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.