SCHEMBL21829113

SCHEMBL21829113

C[Si](C)(C)OC(CCCOCC1CO1)O[Si](C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.55
ALDH1A1 P00352 4/20 0.51
TDP1 Q9NUW8 1/20 0.51
MAPK1 P28482 1/20 0.39
PDK1 Q15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30466596 0.85 TSHR (0.55) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL6912380 0.82 TSHR (0.61) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL29477898 0.81 TSHR (0.59) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL6535136 0.79 TSHR (0.61) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL10585663 0.78 TSHR (0.65) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL15043690 0.77 TSHR (0.64) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL29276580 0.76 SMN1; SMN2 (0.54) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL150316 0.76 TSHR (0.52) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL24293924 0.75 TSHR (0.61) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL10452902 0.75 ALDH1A1 (0.65) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3861039-B1 HYDROGEL COMPOSITIONS OPHTALMIC CIE (FR) 2023-11-01 EP disclosed
US-20210369911-A1 HYDROGEL COMPOSITIONS UNIVERSITÉ DE HAUTE-ALSACE (FR) 2021-12-02 US disclosed
US-20210332174-A1 HYDROGEL COMPOSITIONS OPHTALMIC COMPAGNIE (FR) 2021-10-28 US disclosed
EP-3861042-A1 HYDROGEL COMPOSITIONS Ophtalmic Compagnie (FR) 2021-08-11 EP disclosed
EP-3861039-A1 HYDROGEL COMPOSITIONS Ophtalmic Compagnie (FR) 2021-08-11 EP disclosed
WO-2020070423-A1 HYDROGEL COMPOSITIONS OPHTALMIC COMPAGNIE (FR) 2020-04-09 WO disclosed
WO-2020070422-A1 HYDROGEL COMPOSITIONS OPHTALMIC COMPAGNIE (FR) 2020-04-09 WO disclosed