Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL885152 | 0.82 | CA2 (0.54) | CA2MAPK1CA1ACE2MAPT | |
| Bicarbonate SCHEMBL28584877 | 0.82 | CA2 (0.54) | CA2MAPK1CA1ACE2MAPT | |
| Bicarbonate SCHEMBL216624 | 0.82 | CA2 (0.54) | CA2MAPK1CA1ACE2MAPT | |
| Bicarbonate SCHEMBL28895715 | 0.82 | CA2 (0.54) | CA2MAPK1CA1ACE2MAPT | |
| Bicarbonate SCHEMBL9230330 | 0.80 | CA2 (0.52) | CA2MAPK1CA1ACE2MAPT | |
| Bicarbonate SCHEMBL973799 | 0.80 | CA2 (0.52) | CA2MAPK1CA1ACE2MAPT | |
| Bicarbonate SCHEMBL16738136 | 0.78 | TSHR (0.42) | TSHRTDP1 | |
| Bicarbonate SCHEMBL28900979 | 0.77 | CA2 (0.42) | CA2MAPK1CA1ACE2CTSK | |
| Acetic Acid SCHEMBL4207526 | 0.76 | CA2 (0.52) | CA2MAPK1CA1ACE2CTSK | |
| Acetic Acid SCHEMBL9623423 | 0.74 | ACE2 (0.53) | CA2MAPK1CA1ACE2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020059715-A1 | FILM FOR MANUFACTURING MOLD, MOLDING METHOD, MOLDED ARTICLE, AND CURABLE COMPOSITION FOR MANUFACTURING MOLD | 富士フイルム株式会社 | 2020-03-26 | — | — | WO | disclosed |