Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 3/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14852833 | 0.77 | GLO1 (0.43) | PDE3BPDE3AAHRPDK2ALDH1A1 | |
| SCHEMBL16268739 | 0.73 | NOX1 (0.45) | PDE3BPDE3AAHRPDK2ALDH1A1 | |
| SCHEMBL7442913 | 0.72 | CHEK1 (0.51) | PDE2APDE3BPDE3AAHRPDK2 | |
| SCHEMBL8803451 | 0.71 | ALDH1A1 (0.46) | PDE2APDE3BPDE3AALDH1A1MAPT | |
| SCHEMBL30796831 | 0.71 | AHR (0.59) | PDE3BPDE3AAHRPDK2TDP2 | |
| Acridine SCHEMBL28171509 | 0.71 | ALDH1A1 (0.60) | PDE2APDE3BPDE3AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL27695757 | 0.70 | ALDH1A1 (0.45) | PDE2APDE3BPDE3AALDH1A1MAPT | |
| SCHEMBL5228125 | 0.69 | CASP1 (0.43) | PDE2APDE3BPDE3AALDH1A1MAPT | |
| SCHEMBL30466533 | 0.69 | ALDH1A1 (0.42) | PDE2APDE3BPDE3AALDH1A1MAPT | |
| SCHEMBL8655272 | 0.68 | AHR (0.44) | PDE3BPDE3AAHRPDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3845532-B1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC (CN) | 2022-12-21 | — | — | EP | disclosed |
| EP-3845532-B1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC (CN) | 2022-12-21 | — | — | EP | disclosed |
| US-11230549-B2 | Quinolino-pyrrolidin-2-one derivative and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2022-01-25 | — | — | US | disclosed |
| US-11230549-B2 | Quinolino-pyrrolidin-2-one derivative and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2022-01-25 | — | — | US | disclosed |
| US-20210380599-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2021-12-09 | — | — | US | disclosed |
| US-20210380599-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2021-12-09 | — | — | US | disclosed |
| WO-2021197339-A1 | CRYSTAL FORM OF QUINOPYRROLIDINE-2-ONE COMPOUND SERVING AS ATM INHIBITOR AND USE THEREOF | 南京明德新药研发有限公司 | 2021-10-07 | — | — | WO | disclosed |
| EP-3845532-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2021-07-07 | — | — | EP | disclosed |
| EP-3845532-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020063855-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
| WO-2020063855-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230549-B2 | Quinolino-pyrrolidin-2-one derivative and application thereof | ATM, CHEK2, CHEK1 | PDE2A 968/4885PDE3B 1620/4885PDE3A 1423/4885 |
| US-20210380599-A1 | QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF | ATM, CHEK2, CHEK1 | PDE2A 968/4885PDE3B 1620/4885PDE3A 1423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.