Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20766728 | 0.82 | KDM4E (0.47) | FFAR4KDM4ESLC6A4SLC6A3NPC1 | |
| SCHEMBL2610714 | 0.80 | CHEK1 (0.47) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL187037 | 0.80 | FFAR4 (0.59) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL24744882 | 0.78 | ALDH1A1 (0.37) | FFAR4KDM4EMAPTNPSR1KMT2A | |
| SCHEMBL30122007 | 0.78 | ALDH1A1 (0.37) | FFAR4KDM4EMAPTNPSR1KMT2A | |
| SCHEMBL18018670 | 0.76 | EGFR (0.48) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL24819287 | 0.75 | KDM4E (0.35) | FFAR4OPRK1KDM4ENPC1RAB9A | |
| SCHEMBL21621554 | 0.75 | SLC6A4 (0.45) | ABL1KDM4ESLC6A4SLC6A3NPC1 | |
| SCHEMBL18878112 | 0.75 | CES2 (0.44) | KDM4ESLC6A4SLC6A3NPC1RAB9A | |
| SCHEMBL14719381 | 0.75 | SLC6A4 (0.41) | ABL1KDM4ESLC6A4SLC6A3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085212-B | Isoindoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2023-05-02 | — | — | CN | disclosed |
| CN-114085212-A | Isoindoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2022-02-25 | — | — | CN | disclosed |
| CN-110963994-B | Isoindoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2022-02-08 | — | — | CN | disclosed |
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |
| CN-110963994-A | Isoindoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2020-04-07 | — | — | CN | disclosed |
| WO-2020064002-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国科学院上海药物研究所 | 2020-04-02 | — | — | WO | disclosed |