Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24744882 | 1.00 | ALDH1A1 (0.37) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL24745723 | 0.88 | ALDH1A1 (0.36) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL31443911 | 0.85 | ALDH1A1 (0.39) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL24744883 | 0.84 | MTNR1A (0.34) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL20510109 | 0.83 | FFAR4 (0.52) | ALDH1A1HPGDMEN1KMT2AHSD17B10 | |
| SCHEMBL24745568 | 0.80 | HPGD (0.39) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL21834936 | 0.78 | CHEK1 (0.41) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL20766728 | 0.76 | KDM4E (0.47) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL29346885 | 0.75 | MRGPRX4 (0.42) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL24745340 | 0.74 | ALOX5AP (0.36) | ALDH1A1HPGDMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347579-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | Captor Therapeutics S.A. (PL) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |