Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28979820 | 0.96 | ALDH1A1 (0.60) | ALDH1A1TSHRTDP1TGFBR1THRB | |
| Glycerin SCHEMBL3920132 | 0.87 | ALDH1A1 (0.65) | ALDH1A1TSHRTGFBR1THRBMEN1 | |
| Propylene Glycol SCHEMBL28832507 | 0.86 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1TGFBR1THRB | |
| Isopropyl Alcohol SCHEMBL8941585 | 0.86 | ALDH1A1 (0.79) | ALDH1A1TSHRTDP1TGFBR1THRB | |
| Isobutane SCHEMBL28228894 | 0.84 | ALDH1A1 (0.83) | ALDH1A1TSHRTDP1TGFBR1THRB | |
| Glycerin SCHEMBL23495996 | 0.83 | ALDH1A1 (0.60) | ALDH1A1TSHRTGFBR1THRBEGLN1 | |
| Methacrylic Acid SCHEMBL16266235 | 0.83 | ALDH1A1 (0.60) | ALDH1A1TSHRTDP1TGFBR1THRB | |
| Mannitol SCHEMBL28871183 | 0.83 | ALDH1A1 (0.60) | ALDH1A1TSHRTDP1TGFBR1THRB | |
| Propylene Glycol SCHEMBL3005718 | 0.83 | TSHR (0.44) | ALDH1A1TSHRTDP1TGFBR1THRB | |
| Propylene Glycol SCHEMBL2881547 | 0.83 | TSHR (0.47) | ALDH1A1TSHRTDP1TGFBR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3636720-A1 | USE OF A THICKENED ALCOHOLIC COMPOSITION FOR VERTICAL, BUBBLE-FREE ADHESION OF SUBSTRATES AND METHOD FOR VERTICALLY JOINING TWO SUBSTRATES | tesa SE (DE) | 2020-04-15 | — | — | EP | disclosed |
| EP-3633002-A2 | METHOD FOR APPLYING STAMPED PARTS TO SURFACES AND TEST METHOD FOR SAME | tesa SE (DE) | 2020-04-08 | — | — | EP | disclosed |
| CN-110785395-A | Alkoxylation of hydroxy acids | 巴斯夫欧洲公司 | 2020-02-11 | — | — | CN | disclosed |
| CN-102458837-A | Laminated structure | PILKINGTON GROUP LTD | 2012-05-16 | — | — | CN | disclosed |