Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL21836014 | 0.83 | ALDH1A1 (0.65) | TSHRTDP1ALDH1A1THRBTGFBR1 | |
| Ethylene Glycol SCHEMBL2879183 | 0.81 | ALDH1A1 (0.48) | TSHRTDP1ALDH1A1THRBTGFBR1 | |
| Propylene Glycol SCHEMBL5478391 | 0.81 | THRB (0.57) | TSHRTDP1ALDH1A1THRBTGFBR1 | |
| SCHEMBL28195391 | 0.81 | ALDH1A1 (0.58) | TSHRTDP1ALDH1A1THRB | |
| SCHEMBL179937 | 0.81 | — | — | |
| SCHEMBL8767405 | 0.81 | ALDH1A1 (0.58) | TSHRTDP1ALDH1A1THRB | |
| Propylene Glycol SCHEMBL10455995 | 0.79 | TSHR (0.53) | TSHRTDP1ALDH1A1THRB | |
| Propylene Glycol SCHEMBL3005718 | 0.79 | TSHR (0.44) | TSHRTDP1ALDH1A1THRBTGFBR1 | |
| Propylene Glycol SCHEMBL28979820 | 0.79 | ALDH1A1 (0.60) | TSHRTDP1ALDH1A1THRBTGFBR1 | |
| Propane SCHEMBL28822763 | 0.79 | ALDH1A1 (0.50) | TSHRTDP1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776937-B2 | Photocurable composition for forming an anti-fogging coating | KANSAI PAINT CO., LTD. (JP) | 2010-08-17 | — | — | US | disclosed |
| US-20080118658-A1 | Photocurable Composition for Forming an Anti-Fogging Coating | KANSAI PAINT CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1806388-A1 | PHOTOCURABLE COMPOSITION FOR FORMING ANTIFOG COATING | KANSAI PAINT CO., LTD. (JP) | 2007-07-11 | — | — | EP | disclosed |