Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896511 | 0.71 | DYRK1A (0.65) | DYRK1AUHRF1MAP4K4CCNCCDK8 | |
| SCHEMBL30308690 | 0.71 | DYRK1A (0.65) | DYRK1AUHRF1MAP4K4CCNCCDK8 | |
| Iodide SCHEMBL9618570 | 0.69 | DYRK1A (0.63) | DYRK1AUHRF1MAP4K4CCNCCDK8 | |
| SCHEMBL18406785 | 0.65 | DYRK1A (0.53) | DYRK1AUHRF1MAP4K4CCNCCDK8 | |
| SCHEMBL8964255 | 0.64 | DYRK1A (0.62) | DYRK1AUHRF1MAP4K4CCNCCDK8 | |
| SCHEMBL31119862 | 0.64 | DYRK1A (0.62) | DYRK1AUHRF1MAP4K4CCNCCDK8 | |
| SCHEMBL27971540 | 0.63 | WNT3A (0.52) | DYRK1AUHRF1MAP4K4CCNCCDK8 | |
| SCHEMBL30559511 | 0.62 | DYRK1A (0.60) | DYRK1AUHRF1MAP4K4CDC7ROCK2 | |
| SCHEMBL134658 | 0.62 | DYRK1A (0.60) | DYRK1AUHRF1MAP4K4CDC7ROCK2 | |
| Hydrochloric Acid SCHEMBL30657718 | 0.62 | DYRK1A (0.60) | DYRK1AUHRF1MAP4K4CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | DYRK1A 4479/4885UHRF1 4060/4885MAP4K4 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.