Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21837269 | 0.89 | CHRM1 (0.46) | CHRM1L3MBTL3L3MBTL1MEN1KMT2A | |
| SCHEMBL21837261 | 0.85 | CHRM1 (0.64) | CHRM1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31348822 | 0.85 | ABL1 (0.44) | SMN1; SMN2POLBABL1RIN1ALDH1A1 | |
| SCHEMBL21837270 | 0.81 | CHRM1 (0.42) | CHRM1L3MBTL3L3MBTL1MEN1KMT2A | |
| SCHEMBL18825283 | 0.81 | CHRM1 (0.42) | CHRM1L3MBTL3L3MBTL1MEN1KMT2A | |
| SCHEMBL18825281 | 0.81 | CHRM1 (0.42) | CHRM1L3MBTL3L3MBTL1MEN1KMT2A | |
| SCHEMBL21837271 | 0.81 | CHRM1 (0.42) | CHRM1L3MBTL3L3MBTL1MEN1KMT2A | |
| SCHEMBL18825113 | 0.81 | L3MBTL3 (0.45) | CHRM1L3MBTL3L3MBTL1MEN1KMT2A | |
| SCHEMBL28037969 | 0.80 | CHRM1 (0.56) | CHRM1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL16210548 | 0.77 | SMN1; SMN2 (0.51) | CHRM1L3MBTL3L3MBTL1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3797778-A1 | OXIME COMPOUNDS AS AGONISTS OF THE MUSCARINIC M1 AND/OR M4 RECEPTOR | Heptares Therapeutics Limited (GB) | 2021-03-31 | — | — | EP | disclosed |
| EP-3370828-B1 | OXIME COMPOUNDS AS AGONISTS OF THE MUSCARINIC M1 AND/OR M4 RECEPTOR | HEPTARES THERAPEUTICS LTD (GB) | 2020-04-15 | — | — | EP | disclosed |