Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 7/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788402 | 1.00 | ADORA3 (0.34) | ADORA3EGFRERBB3AURKAAURKB | |
| SCHEMBL21837314 | 0.95 | ADORA3 (0.34) | ADORA3EGFRERBB3AURKAAURKB | |
| SCHEMBL21837302 | 0.89 | GPR119 (0.31) | — | |
| SCHEMBL21837309 | 0.88 | GPR119 (0.32) | AURKAAURKBRPS6KB1BRD4 | |
| SCHEMBL17453463 | 0.85 | — | — | |
| SCHEMBL21837304 | 0.82 | ADORA3 (0.36) | ADORA3EGFRERBB3AURKAAURKB | |
| SCHEMBL17453456 | 0.81 | RPS6KB1 (0.31) | AURKAAURKBRPS6KB1 | |
| SCHEMBL31678879 | 0.80 | — | — | |
| SCHEMBL17479810 | 0.80 | GPR119 (0.30) | — | |
| SCHEMBL17453474 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023650-A1 | 4'-SUBSTITUTED-FURO[3,2-D]PYRIMIDINE AND -PYRROLO[3,2- D]PYRIMIDINE DERIVATIVES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| EP-3693367-A1 | THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3174870-B1 | THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2020-04-15 | — | — | EP | disclosed |