SCHEMBL21837302

CC(C)(C)[Si](C)(C)OC[C@@]1(CO)O[C@@H](c2csc3c(NC(=O)c4ccccc4)ncnc23)[C@H](F)[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	GPR119	Q8TDV5	2/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL21837309	0.95	GPR119 (0.32)	GPR119
SCHEMBL21837308	0.89	ADORA3 (0.34)	—
SCHEMBL17479810	0.88	GPR119 (0.30)	GPR119
SCHEMBL21837314	0.88	ADORA3 (0.34)	—
SCHEMBL17453474	0.87	—	—
SCHEMBL29788374	0.87	—	—
SCHEMBL17453456	0.87	RPS6KB1 (0.31)	GPR119
SCHEMBL21837311	0.86	—	—
SCHEMBL17465425	0.82	BRD4 (0.34)	—
SCHEMBL19644596	0.82	BRD4 (0.35)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4023650-A1	4'-SUBSTITUTED-FURO[3,2-D]PYRIMIDINE AND -PYRROLO[3,2- D]PYRIMIDINE DERIVATIVES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	Gilead Sciences, Inc. (US)	2022-07-06	—	—	EP	disclosed
EP-3693367-A1	THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	Gilead Sciences, Inc. (US)	2020-08-12	—	—	EP	disclosed
EP-3174870-B1	THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS	GILEAD SCIENCES INC (US)	2020-04-15	—	—	EP	disclosed