Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17465417 | 1.00 | PDPK1 (0.31) | PDPK1BRD4HCAR3 | |
| SCHEMBL17453491 | 0.84 | ADORA2A (0.34) | — | |
| SCHEMBL19644596 | 0.80 | BRD4 (0.35) | PDPK1BRD4HCAR3 | |
| SCHEMBL31406971 | 0.80 | AURKA (0.32) | — | |
| SCHEMBL16708516 | 0.77 | POLRMT (0.42) | — | |
| SCHEMBL17465423 | 0.77 | TMPRSS2 (0.34) | PDPK1BRD4HCAR3 | |
| SCHEMBL17465407 | 0.76 | PDPK1 (0.35) | PDPK1BRD4 | |
| SCHEMBL17465398 | 0.75 | BRD4 (0.34) | PDPK1BRD4HCAR3 | |
| SCHEMBL17465425 | 0.75 | BRD4 (0.34) | PDPK1BRD4HCAR3 | |
| SCHEMBL17465396 | 0.75 | LGALS9 (0.38) | PDPK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023650-A1 | 4'-SUBSTITUTED-FURO[3,2-D]PYRIMIDINE AND -PYRROLO[3,2- D]PYRIMIDINE DERIVATIVES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| EP-3693367-A1 | THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3174870-B1 | THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2020-04-15 | — | — | EP | disclosed |