Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | NT5C2 | P49902 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17465425 | 0.91 | BRD4 (0.34) | BRD4PDPK1HCAR3CSF1RNT5C2 | |
| SCHEMBL17465406 | 0.88 | PDPK1 (0.33) | BRD4PDPK1HCAR3CSF1RNPSR1 | |
| SCHEMBL17465419 | 0.88 | PDPK1 (0.33) | BRD4PDPK1HCAR3CSF1RNPSR1 | |
| SCHEMBL17465423 | 0.87 | TMPRSS2 (0.34) | BRD4PDPK1HCAR3CSF1RNT5C2 | |
| SCHEMBL17465398 | 0.85 | BRD4 (0.34) | BRD4PDPK1HCAR3NT5C2NPSR1 | |
| SCHEMBL21837309 | 0.85 | GPR119 (0.32) | BRD4PDPK1CSF1RAURKARPS6KB1 | |
| SCHEMBL17465429 | 0.83 | PDPK1 (0.33) | BRD4PDPK1HCAR3CSF1RNT5C2 | |
| SCHEMBL21837302 | 0.82 | GPR119 (0.31) | — | |
| SCHEMBL17479346 | 0.81 | LGALS9 (0.38) | BRD4PDPK1ADORA3ADORA2AADORA1 | |
| SCHEMBL17465396 | 0.81 | LGALS9 (0.38) | BRD4PDPK1ADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828388-B2 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2017-11-28 | — | — | US | disclosed |