Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21838618 | 0.84 | RIPK1 (0.32) | NPC1RAB9A | |
| SCHEMBL21838539 | 0.84 | CNR2 (0.40) | — | |
| SCHEMBL21838641 | 0.78 | KMO (0.37) | NOTUMKMOHSD11B1POLQ | |
| SCHEMBL21838602 | 0.78 | KMO (0.37) | NOTUMKMOHSD11B1POLQ | |
| SCHEMBL20063855 | 0.77 | KDM1A (0.39) | — | |
| SCHEMBL20063853 | 0.77 | KDM1A (0.39) | — | |
| SCHEMBL21838557 | 0.76 | APP (0.36) | — | |
| SCHEMBL21838644 | 0.71 | SCN9A (0.39) | HSD11B1 | |
| SCHEMBL21838611 | 0.71 | RXFP1 (0.31) | NPC1RAB9A | |
| SCHEMBL21838628 | 0.70 | AKR1C3 (0.44) | HSD11B1POLQNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115354-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115354-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | NPY5R, REN, F12 | NOTUM 3035/4885KMO 1181/4885HSD11B1 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.