Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.42 |
| ▸ | GIGYF2 | Q6Y7W6 | 1/20 | 0.42 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | RNF168 | Q8IYW5 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669552 | 0.94 | ITGB1 (0.47) | ITGB1ITGA4CDK8SLC6A3WDR5 | |
| SCHEMBL19361185 | 0.86 | ITGB1 (0.46) | ITGB1ITGA4CDK8SLC6A3WDR5 | |
| SCHEMBL19365793 | 0.86 | ITGB1 (0.46) | ITGB1ITGA4CDK8SLC6A3WDR5 | |
| SCHEMBL19361184 | 0.86 | ITGB1 (0.46) | ITGB1ITGA4CDK8SLC6A3WDR5 | |
| SCHEMBL19365797 | 0.86 | TP53 (0.38) | CA2CA9 | |
| SCHEMBL19670273 | 0.80 | CDK8 (0.46) | ITGB1ITGA4CDK8SLC6A3WDR5 | |
| SCHEMBL19365540 | 0.79 | CA2 (0.38) | CA2CA9 | |
| SCHEMBL17624649 | 0.76 | CA12 (0.49) | ITGB1ITGA4CDK8WDR5CA12 | |
| SCHEMBL16249966 | 0.76 | CA12 (0.49) | ITGB1ITGA4CDK8WDR5CA12 | |
| SCHEMBL19365477 | 0.75 | CDK8 (0.45) | ITGB1ITGA4CDK8SLC6A3WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590135-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2020-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590135-B2 | Substituted bridged urea analogs as sirtuin modulators | SIRT1, SIRT3, SIRT2 | ITGB1 4637/4885ITGA4 4813/4885CDK8 530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.