Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3259625 | 0.95 | RAD52 (0.37) | ALDH1A1GAACYP2D6DCTPP1RAD52 | |
| SCHEMBL2182806 | 0.94 | ALDH1A1 (0.42) | ALDH1A1GAACYP2D6DCTPP1RAD52 | |
| SCHEMBL2179530 | 0.91 | ALDH1A1 (0.36) | ALDH1A1CYP2D6DCTPP1TSHRHSD17B10 | |
| SCHEMBL2183045 | 0.90 | RAD52 (0.43) | ALDH1A1GAADCTPP1RAD52TSHR | |
| SCHEMBL2182969 | 0.88 | PCSK9 (0.41) | ALDH1A1CYP2D6DCTPP1TSHRHSD17B10 | |
| SCHEMBL2181859 | 0.86 | TSHR (0.36) | ALDH1A1CYP2D6DCTPP1TSHRHSD17B10 | |
| SCHEMBL2182838 | 0.86 | DCTPP1 (0.38) | ALDH1A1CYP2D6DCTPP1TSHRHSD17B10 | |
| SCHEMBL2182270 | 0.84 | ALDH1A1 (0.37) | ALDH1A1GAACYP2D6DCTPP1RAD52 | |
| SCHEMBL2182082 | 0.84 | ALDH1A1 (0.40) | ALDH1A1CYP2D6DCTPP1TSHRHSD17B10 | |
| SCHEMBL2182078 | 0.84 | DCTPP1 (0.37) | ALDH1A1CYP2D6DCTPP1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | DPYD, TYMP, DHFR | ALDH1A1 245/4885GAA 1134/4885CYP2D6 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.