Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.32 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99220 | 0.81 | TPH1 (0.34) | DGAT1 | |
| SCHEMBL2144873 | 0.77 | CTSL (0.31) | — | |
| SCHEMBL2144864 | 0.75 | JAK2 (0.39) | — | |
| SCHEMBL2144867 | 0.75 | — | — | |
| SCHEMBL101697 | 0.75 | DGAT1 (0.34) | DGAT1 | |
| SCHEMBL101565 | 0.73 | — | — | |
| SCHEMBL4086968 | 0.72 | JAK2 (0.36) | — | |
| SCHEMBL2185614 | 0.70 | TPH1 (0.35) | DGAT1 | |
| SCHEMBL2145094 | 0.70 | CYP3A4 (0.35) | — | |
| SCHEMBL101261 | 0.69 | JAK2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474545-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2343298-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2011-07-13 | — | — | EP | disclosed |