Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28460855 | 0.87 | P2RX7 (0.31) | CREBBPBRD4EP300 | |
| SCHEMBL22716158 | 0.81 | MTHFD2 (0.33) | DPP4DPP8DPP9DPP7CREBBP | |
| SCHEMBL22719403 | 0.81 | MTHFD2 (0.33) | DPP4DPP8DPP9DPP7CREBBP | |
| SCHEMBL22492311 | 0.79 | ADORA1 (0.47) | MAPK1 | |
| SCHEMBL22492335 | 0.76 | DHFR (0.54) | — | |
| SCHEMBL17785865 | 0.74 | CREBBP (0.44) | CREBBPBRD4EP300MAPK1 | |
| SCHEMBL2923652 | 0.73 | CCNA2 (0.38) | CREBBPBRD4EP300MAPK1 | |
| SCHEMBL22492447 | 0.73 | CYP2C19 (0.50) | — | |
| SCHEMBL24209724 | 0.71 | ADORA1 (0.43) | MAPK1 | |
| SCHEMBL22126903 | 0.71 | BRD4 (0.31) | DPP4DPP8DPP9DPP7CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354644-B | Pyrazolopyrimidine compound used as DPP-IV inhibitor and application thereof | 烟台药物研究所 | 2023-07-04 | — | — | CN | disclosed |
| CN-113861196-B | DPP-IV inhibitor with 4, 6-disubstituted pyrimidine structure and application thereof | 烟台药物研究所 | 2023-06-02 | — | — | CN | disclosed |
| CN-113861196-A | DPP-IV inhibitor with 4, 6-disubstituted pyrimidine structure and application thereof | 烟台药物研究所 | 2021-12-31 | — | — | CN | disclosed |
| CN-113354644-A | Pyrazolopyrimidine structure compound used as DPP-IV inhibitor and application thereof | 烟台药物研究所 | 2021-09-07 | — | — | CN | disclosed |
| CN-111670034-A | Pyranopyrazoles and pyrazolopyridines immunomodulators for the treatment of autoimmune diseases | 洛克菲勒大学 | 2020-09-15 | — | — | CN | disclosed |
| WO-2020081636-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-04-23 | — | — | WO | disclosed |