Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | UBE2M | P61081 | 6/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 4/20 | 0.39 |
| ▸ | MLNR | O43193 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856317 | 0.78 | IDH2 (0.43) | IDH2EPHX2UBE2MDCUN1D1KMT2A | |
| SCHEMBL21856323 | 0.78 | IDH2 (0.45) | IDH2EPHX2UBE2MDCUN1D1KMT2A | |
| SCHEMBL21959807 | 0.74 | IDH2 (0.47) | IDH2EPHX2UBE2MDCUN1D1KMT2A | |
| SCHEMBL24781071 | 0.74 | TEAD1 (0.45) | IDH2EPHX2UBE2MDCUN1D1KMT2A | |
| SCHEMBL24781281 | 0.72 | IDH2 (0.62) | IDH2EPHX2UBE2MDCUN1D1KMT2A | |
| SCHEMBL21856333 | 0.72 | PHGDH (0.46) | IDH2EPHX2KMT2APHGDHMLNR | |
| SCHEMBL21856359 | 0.72 | PHGDH (0.46) | IDH2EPHX2KMT2APHGDHMLNR | |
| SCHEMBL21856338 | 0.72 | PHGDH (0.46) | IDH2EPHX2KMT2APHGDHMLNR | |
| SCHEMBL21856302 | 0.71 | EPHX2 (0.45) | IDH2EPHX2KMT2APHGDHMLNR | |
| SCHEMBL21856340 | 0.71 | MALT1 (0.43) | IDH2EPHX2UBE2MDCUN1D1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |