Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.43 |
| ▸ | UBE2M | P61081 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.43 |
| ▸ | PHGDH | O43175 | 4/20 | 0.42 |
| ▸ | MLNR | O43193 | 2/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21959807 | 0.89 | IDH2 (0.47) | IDH2EPHX2DCUN1D1UBE2MMEN1 | |
| SCHEMBL21856357 | 0.88 | RHOC (0.40) | IDH2EPHX2DCUN1D1UBE2MMEN1 | |
| SCHEMBL21856354 | 0.82 | EGFR (0.39) | IDH2 | |
| SCHEMBL21856326 | 0.82 | RHOC (0.42) | DCUN1D1UBE2M | |
| SCHEMBL21959809 | 0.82 | EPHX2 (0.50) | IDH2EPHX2MEN1KMT2AMALT1 | |
| SCHEMBL21856309 | 0.82 | SPR (0.43) | — | |
| SCHEMBL21958711 | 0.81 | MALT1 (0.46) | IDH2EPHX2MEN1KMT2AMALT1 | |
| SCHEMBL21856319 | 0.81 | ALDH1A1 (0.42) | DCUN1D1UBE2MMEN1KMT2A | |
| SCHEMBL21856343 | 0.81 | TAS2R14 (0.37) | IDH2DCUN1D1UBE2MMEN1KMT2A | |
| SCHEMBL21856348 | 0.80 | PABPC1 (0.40) | EPHX2DCUN1D1UBE2MKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |