SCHEMBL2186555

SCHEMBL2186555

C(=Cc1ccc(-c2nnnc(-c3ccccc3)c2-c2ccccc2)cc1)c1ccc(-c2nnnc(-c3ccccc3)c2-c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.44
HTT P42858 1/20 0.44
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CA1 P00915 1/20 0.40
MGLL Q99685 1/20 0.40
PTGS1 P23219 1/20 0.39
PTGS2 P35354 1/20 0.39
SMN1; SMN2 Q16637 5/20 0.38
KDM4E B2RXH2 3/20 0.38
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
HPGD P15428 2/20 0.38
MAPT P10636 2/20 0.38
NFE2L2 Q16236 1/20 0.38
CYP19A1 P11511 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
HDAC2 Q92769 2/20 0.37
ALDH1A1 P00352 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2186549 1.00 LMNA (0.44) LMNAHTTMEN1KMT2ACA1
SCHEMBL30979146 1.00 LMNA (0.44) LMNAHTTMEN1KMT2ACA1
SCHEMBL22360955 0.88 LMNA (0.54) LMNAHTTMEN1KMT2APTGS1
SCHEMBL500715 0.85 LMNA (0.56) LMNAHTTMEN1KMT2APTGS1
SCHEMBL28583462 0.83 NFE2L2 (0.40) LMNAHTTMEN1KMT2APTGS1
Water SCHEMBL28964119 0.81 LMNA (0.52) LMNAHTTMEN1KMT2APTGS1
Water SCHEMBL28150223 0.81 LMNA (0.52) LMNAHTTMEN1KMT2APTGS1
SCHEMBL17287226 0.78 ALDH1A1 (0.54) LMNAHTTSMN1; SMN2NPC1RAB9A
SCHEMBL31208445 0.76 BRD4 (0.44) LMNASMN1; SMN2KDM4EALDH1A1HSD17B10
Diphenylamine SCHEMBL11692790 0.74 HSD17B10 (0.48) LMNAHTTMEN1KMT2APTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2353576-A1 Tooth coating material GC Corporation (JP) 2011-08-10 EP claimed
US-20250064687-A1 DENTAL CURABLE COMPOSITION AND DENTAL PROSTHESIS COMPRISING BASE MATERIAL AND RESIN LAYER KURARAY NORITAKE DENTAL INC. (JP) 2025-02-27 US disclosed
US-20250026917-A1 ULTRAVIOLET-CURABLE RESIN COMPOSITION, ADHESIVE, SEALANT, INSULATING PROTECTIVE AGENT, AND ELECTRONIC CIRCUIT BOARD PELNOX, LTD. (JP) 2025-01-23 US disclosed
EP-4458344-A1 DENTAL CURABLE COMPOSITION AND DENTAL PROSTHESIS COMPRISING BASE MATERIAL AND RESIN LAYER Kuraray Noritake Dental Inc. (JP) 2024-11-06 EP disclosed
WO-2023127794-A1 DENTAL CURABLE COMPOSITION AND DENTAL PROSTHESIS COMPRISING BASE MATERIAL AND RESIN LAYER クラレノリタケデンタル株式会社 2023-07-06 WO disclosed
WO-2023038001-A1 ULTRAVIOLET-CURABLE RESIN COMPOSITION, ADHESIVE, SEALANT, INSULATING PROTECTIVE AGENT, AND ELECTRONIC CIRCUIT BOARD 荒川化学工業株式会社 2023-03-16 WO disclosed
EP-2163233-B1 Paste-type dental cement G C DENTAL IND CORP (JP) 2011-07-13 EP disclosed
EP-2163233-A1 Paste-type dental cement GC Corporation (JP) 2010-03-17 EP disclosed
US-20100063176-A1 PASTE-TYPE DENTAL CEMENT GC CORPORATION (JP) 2010-03-11 US disclosed
EP-1226807-B1 DENTAL CURABLE COMPOSITION TOKUYAMA CORP (JP) 2008-08-13 EP disclosed
EP-1226807-A1 DENTAL CURABLE COMPOSITION TOKUYAMA CORPORATION (JP) 2002-07-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250064687-A1 DENTAL CURABLE COMPOSITION AND DENTAL PROSTHESIS COMPRISING BASE MATERIAL AND RESIN LAYER MGMT, SEM1, CARM1 LMNA 2926/4885HTT 3700/4885MEN1 3326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.