Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PMM2 | O15305 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9013992 | 0.86 | TSHR (0.49) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL27338694 | 0.83 | ALDH1A1 (0.42) | ALDH1A1TDP1TSHRMAPT | |
| SCHEMBL16387622 | 0.81 | MEN1 (0.43) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL28249903 | 0.78 | MEN1 (0.44) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL27853733 | 0.76 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1TDP1TSHR | |
| SCHEMBL11695700 | 0.76 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TDP1TSHR | |
| SCHEMBL18350282 | 0.75 | GRIN2D (0.41) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL594277 | 0.75 | GPR35 (0.44) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL27935928 | 0.75 | KMT2A (0.39) | MEN1KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL28226522 | 0.75 | ALDH1A1 (0.41) | KMT2AGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846799-B1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2017-11-15 | — | — | EP | disclosed |
| US-9296750-B2 | Spirolactam CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-04-23 | — | — | US | disclosed |
| EP-2846799-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013169567-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-11-14 | — | — | WO | disclosed |
| US-20110245240-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2011-10-06 | — | — | US | disclosed |
| EP-2341919-A1 | CGRP RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010042356-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245240-A1 | CGRP RECEPTOR ANTAGONISTS | CCKAR, CALCRL, QRFPR | MEN1 1388/4885KMT2A 3375/4885GRIN2D 721/4885 |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, TACR1 | MEN1 877/4885KMT2A 3672/4885GRIN2D 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.