⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10174575 | 0.79 | LMNA (0.42) | — | |
| SCHEMBL293672 | 0.78 | — | — | |
| SCHEMBL17812081 | 0.77 | — | — | |
| SCHEMBL19978685 | 0.77 | LMNA (0.41) | — | |
| SCHEMBL24760033 | 0.76 | — | — | |
| SCHEMBL11163721 | 0.76 | — | — | |
| SCHEMBL17382012 | 0.76 | NOS1 (0.39) | — | |
| SCHEMBL12460156 | 0.76 | NOS1 (0.39) | — | |
| SCHEMBL12460187 | 0.76 | JAK2 (0.39) | — | |
| SCHEMBL15986683 | 0.76 | NOS1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014174307-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2014-10-30 | — | — | WO | disclosed |
| EP-2328896-B1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |
| US-8563576-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-10-22 | — | — | US | disclosed |
| US-8563576-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120184534-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-07-19 | — | — | US | disclosed |
| US-20120184534-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-07-19 | — | — | US | disclosed |
| EP-1710234-B1 | MALONONITRILE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010011768-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-28 | — | — | WO | disclosed |
| US-7541374-B2 | Malononitrile compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-06-02 | — | — | US | disclosed |
| US-7541374-B2 | Malononitrile compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20070117854-A1 | Malononitrile compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-05-24 | — | — | US | disclosed |
| US-20070117854-A1 | Malononitrile compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-05-24 | — | — | US | disclosed |
| EP-1710234-A1 | MALONONITRILE COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2006-10-11 | — | — | EP | disclosed |
| US-4657577-A | LOW DOSAGE, GRASSES, WEEDS | BAYER AKTIENGESELLSCHAFT (DE) | 1987-04-14 | — | — | US | disclosed |
| US-4585870-A | POSTEMERGENCE HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1986-04-29 | — | — | US | disclosed |
| US-4518416-A | Certain trimethyl silyl-lower-alkyl esters of pyridyloxy-phenoxy-lower alkanoic acids, compositions containing same and herbicidal method of use | BAYER AKTIENGESELLSCHAFT (DE) | 1985-05-21 | — | — | US | disclosed |
| EP-0096354-A1 | Substituted pyridyl-phenyl ethers | BAYER AG (DE) | 1983-12-21 | — | — | EP | disclosed |
| EP-0095115-A1 | Substituted diphenyl ethers | BAYER AG (DE) | 1983-11-30 | — | — | EP | disclosed |
| US-4402727-A | Substituted azolylalkyl phenoxyphenoxyalkane-carboxylates as herbicides and plant growth regulators | BAYER AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | disclosed |
| EP-0073880-A2 | Substituted phenoxyphenoxyalkanecarbonacid-azolyl-alkyl esters, process for their preparation and their use as herbicides and plant growth regulators | BAYER AG (DE) | 1983-03-16 | — | — | EP | disclosed |